This study evaluated the blood hematological, immunity, organs lymphoid of combinations safflower oil (SO) and inositol (IN) in female Sentul chicken. A total of 81 birds, was 16 weeks old which were raised throughout 8 weeks. Nine experimental diets were formulated, control diet = SO 0% + IN 0%, SO = 0,5%, IN = 0,5%, SO = 1%, IN = 1%, SO 0,5 % + IN 0,5%, SO 0,5% +IN 1%, SO 1% + IN 0,5%, SO 1% +IN 1%. Used research a completely random design; nine experimental with three repetitions for each replicate of three birds. Were the variables being feed consumption, hematological, titer antibodies against New castle disease, avian influenza, and lymphoidorgans. The results showed the treatments had no significant (p<0.05) feed consumption on the first week of birds while in the second to the six-week application of different levels supplementation safflower oil and inositol application affected was significantly (p>0.05) affected feed consumption and did not significant difference (p >0.05) of hematological, titer antibody of ND,In contrast, AI was highly significantly different (p < 0.01), the spleen and thymus did not have a significant difference (P>0, 05) while the relative weight of bursa of Fabricius was high significantly (P<0, 05). The application supplementation safflower oil with inositol had no negative effect on hematological, still produced relatively similar of blood, increased the feed consumption at (IN 0.5 %), weight in bursa Fabricius at (SO 1%+IN 1%) , increased response immune indices of titer antibody at (SO1%)(IN 1%)( SO 0.5%+IN 1%) this indicates healthy of chicken.
