A comparative study to evaluate effect of iv esmolol and diltiazem to attenuate haemodynamic response to larngoscopy and intubation

Laryngoscopy and endotracheal intubation is integral part of anaesthesia, which is associated with sudden rise in heart rate, blood pressure, intracranial tension which is harmful in patients with poor cardiac reserve. We conducted study in 150 normotensive patients of ASA 1, 2 who are divided in three equal group of 50 each.Group C, Group E, Group D received normal saline, inj esmolol 2mg/kg, and inj diltiazem. 2mg/kg respectively 3 minutes before laryngoscopy. We measured heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure as baseline before induction of anaesthesia,then after induction and 1,3,5, and 10 minutes after laryngoscopy and intubation. We observed for rise or fall in all parameters. Our results are calculated by paired, unpaired ‘t’ test and ‘chi square’ test. Result showed that there is maximum attenuation of all parameters in esmolol group followed by diltiazem group, control group demonstrated maximum rise in all parameters. Thus we can conclude that esmolol offers better attenuation of haemodynamic response to laryngoscopy and intubation than diltiazem without any side effect