Contribution of fasting and postprandial blood glucose towards glycation of hemoglobin in prediabetes

Background: Prediabetes is a stage in the natural history of disordered glucose metabolism rather than a distinctive clinical entity representing an interim condition and a risk factor for the development of diabetes along with an increase in cardiovascular and microvascular complications. So, prediabetes is a state of nondiabetic hyperglycemia that does not satisfy the diagnostic criteria for diabetes mellitus. Objectives: To correlate the levels of fasting blood glucose (FBG) and postprandial blood glucose (PPBG) with glycated hemoglobin (HbA1c) in prediabetics. Materials & Methods: The present case control study was performed at Pt. B. D. Sharma PGIMS, Rohtak includes thirty prediabetes patients of age group 20-40 years diagnosed on the basis of HbA1c (5.7-6.4%). Thirty healthy and age matched control were taken. Venous blood samples were obtained for analysis of fasting blood glucose, postprandial blood glucose and HbA1c after obtaining written consent. Samples were processed by centrifugation and analysed on the same day. Results: The correlation coefficient between fasting blood glucose (108.50 ± 10.51 mg/dL) and HbA1c (5.94 ± 0.21%) is r = 0.444 with p value = 0.014 which is lower than the correlation coefficient between postprandial blood glucose (155.33 ± 13.18 mg/dL) and HbA1c i.e r = 0.648 with p value = 0.001. Conclusion: The contribution of postprandial blood glucose towards glycation of hemoglobin is more than the contribution of fasting blood glucose levels.