Correlation between serum levels anti-cyclic citrullinated peptide antibody and rheumatoid factor in patients with arthralgia

Introduction: Rheumatoid arthritis (RA), which has an estimated worldwide prevalence in adults of 0.8% and more frequently affects females, is characterized by joint inflammation and destruction and gives rise to functional limitations, working disability, and a poor quality of life. The etiology of this disease is unknown; however interaction between both genetic and environmental factors is thought to contribute to its occurrence. Consequently, the purpose of this study was to examinate correlation between RF, CRP, Uric acid and Anti CCP in patients with join pain. Materials and Methods: This study was carried at the Department of medical biochemistry and Department of reumatologu of Public Health Organization Clinical hospital d-r Trifun Panovski in Bitola. Written informed consent was taken from all the subjects before undergoing any investigation. The research protocol was conducted in accordance with the Helsinki Declaration. Results: A total of 50 patients were available for this study and were included in the analysis. From 50 patients, 33 patients (66%) were female and 17 males (34%). The mean age of the cohort was 54 years old ranging from 28 to 84 years old. Serum concentration of anti CCP in all participants was in range <0,5 U/ml to 641 U/ml, mean 23,9 U/ml. Males serum concentration of Anti CCP was in range <0.5 U/ml to 189 U/ml, mean 14,78 U/ml. Females serum concentration of Anti CCP was in range <0.5 U/ml to 641 U/ml, mean 28.7 U/ml. A significant association of RF and anti-CCP antibody co-occurrence was observed: Positive for both RF and anti-CCP antibody were 7 patients (5 female and 2 males). RF-positive/anti-CCP antibody-negative were 12 patients (9 female and 2 males). RF-negative/anti-CCP antibody-positive were 2 female patients. Discussion: We found a significant association of RF and Anti CCP in 36 of 50 patients with arthralgia, which is in a correlation with previous studies. We found that female patients safer frequent from arthralgia compare to males which is in a correlation with previous studies. Conclusion: The usage of anti-CCP antibody is useful in the detection of early disease as evidenced by significant association between anti-CCP antibody and RF.