The Effect Of Andrographis Paniculata Extract Capsules On Blood Glucose Level In Patients With Type 2 Diabetes Mellitus

Andrographis paniculata Nees. (AP) leaves, empirically used as an alternative medicine for various diseases including diabetes mellitus, but the scientific evident for treatment in humans were still limited published reports. This study analyzed the effects of hypoglycemic AP capsules (APC) as an additional therapy in patients with type 2 diabetes mellitus. The design of this study was double-blind randomized controlled trial, cross-over design in 34 subjects who were divided into two groups. The first group received two APC 2 times daily for 14 days, and the second group received 2 placebo capsules (PC) 2 times daily for 14 days. Both groups kept taking metformin as standard therapy, then the evaluation of blood glucose levels on day 14. The result showed that showed that administration of APC for 14 days fasting blood glucose levels (13.47 mg/dL) greater compared to PC (-8 mg/dL) but not significantly. The APC significantly reduced blood glucose 2 hours after meal at 34.91mg/dL and significant (p<0.05).