The impact of tyrosine kinase inhibitors on thyroid function tests among sudanesepatients with chronic myeloid leukemia

Chronic myeloid leukemia used to think as an old type of leukemia, but nowadays any age can get it, it has many reasons but all lead to colonial proliferation of white blood cells (granulocyte mainly) with translocation between chromosome 9 and 22 giving rise a new one called Philadelphia chromosome, which is responsible for abnormal proliferation of myeloid cells. In Khartoum state, an oncology and nuclear medicine hospital is considered as a main treatment center for all kinds of cancer. Ethical approval has been obtained from each of hospital administrator and co- patients to be involved in this study. Under hygienic conditions blood samples were collected anticoagulant free in order to obtain serum, which kept under -20Co, then analyzed for freeT3, freeT4 and TSH as evaluation plan for thyroid function tests while these patients diagnosed with CML and set for drugs anti to the proliferation called tyrosine kinase inhibitors. Thyroid dysfunction appeared to be related to the CML itself rather than be affected with anticarcinogenic drugs, as new case subjects showed significant difference more than those of under treatment, as variation revealed.