Non-cholesterol-dependent biological effects of statins: a new horizon in periodontal therapy

Periodontitis is an inflammatory process causing destruction of the periodontal tissues and alveolar bone. Various adjunctive treatment approaches are introduced along with scaling and root planing for treating periodontitis; Statins being one of them. Statins are considered as “Gold-standard” to treat hyperlipidemia and widely used to control cardiovascular and cerebrovascular diseases. Apart from the lipid-lowering properties, various non-cholesterol-dependent biological effects of statins are captivated. These include Antioxidative, Antibacterial, Antithrombotic, Anti-inflammatory, Immunomodulatory, and Osteomodulatory properties. Considering these effects, this group of drugs might play a potential role in regenerative periodontal therapy.