Prognostic significance of macrophage migration inhibitory factor (mif) and tissue inhibitor of metalloproteinases-1(timp-1) in colorectal cancer (crc).

Background: Colorectal cancer (CRC) is the third most common epithelial malignancy in the world. Colorectal cancer develops slowly from removable precancerous lesions, detection of lesion can reduce the incidence and mortality of this malignancy. Hence the present study was under taken to relate the TIMP-1 and MIF protein analysis that are non- invasive, which may enable us to detect colorectal cancer quite early. Study design: Case control study. Aims and objectives: The present study included total 120 patients diagnosed with colorectal cancer. They categorized as- Group I – included 10 patients with disease dissemination (stage I-IV with recurrences); Group II – 110 patients with non dissemination (stage I-IV without recurrences) and Group III – 120 age and sex matched healthy controls. To rule out the risk of colorectal cancer CEA, Ca 19-9 and fecal hemoglobin were analyzed. Genetic and prognostic markers like, TIMP-1 and MIF protein were analyzed. All statistical analysis was performed by using SPSS software and expressed as mean ± standard deviation, p˂0.005 was considered as statistically significant. Correlations between the parameters were analyzed. Results: The concentration of CEA, Ca19-9, TIMP-1, MIF protein, level were significantly higher in patient group then in controls group (p˂0.005). A significant correlation between CEA and CA19-9, TIMP-1 and MIF were observed. Conclusions: In this study the level of TIMP-1 and MIF expression exhibits an upper moderate diagnostic value in CRC, and this result could offer new approaches in the diagnosis, prognosis and monitoring risk factors in colorectal cancer.