Accumulation of interacting partners and oligomerisation status for protein domains of pass2 single-membered and two-membered superfamilies

Protein-Protein interactions play a major role in carrying out biological functions including enzymatic catalysis, ion transportation and cellular regulation. Systems level understanding of cellular functions uncovers all functional interactions of proteins. It is, thus, important to have resources which make available structural details about these interactions. In present study, a new database called PPI database has been developed which contains information about oligomerisation status, interacting partners and closest homologues for all the structural domains of Single-Membered and Two-Membered Superfamilies of the already existing in-house database, PASS2. Residues present at the protein-protein interface have been analyzed and the ones which provide stability to the complex, i.e. hotspot residues, have been predicted and recorded.