Embryological corelation and clinical perspectives of unilateral agenesis of kidney and ureter in fetus

Birth defects are the leading cause of infant mortality accounting for approximately 21% of infant death rate. Developmental anomalies of the urogenital system is one of them, and of paramount clinical importance. About 100 foetuses of age groups four months to nine months of intrauterine life were collected from local hospitals at Kakatiya Medical College, Warangal, Andhra Pradesh and preserved in 10%formalin. After making an incision in the anterior abdominal wall. The abdomen was eviscerated. The posterior abdominal wall and the excretory organs were exposed on both the sides. Out of 100 foetuses observed, in one foetus (Male, aged 20 weeks) the left kidney, the left ureter and the left renal artery were absent. The foetus had a normal right kidney, right ureter and right renal artery. In conclusion, Renal agenesis is the consequence of failure of development of the ureteric bud.