Ocimum sanctum is a tiny, branched, and fragrant herb that is also referred to as "Tulsi" or "Holy basil." It stands about 70 cm tall. This fragrant plant is grown often close to Hindu homes and temples and is found all across India. The Ayurvedic and Siddha systems of medicine have employed all of this herb's components, including the roots, leaves, and seeds, for thousands of years to treat a variety of illnesses and problems. Due to the abundance of beneficial nutrients and different physiologically active substances, it is quite complicated chemically. With a high degree of safety, several scientific investigations have demonstrated that it has antioxidant, anti-stress, hepatoprotective, immunomodulatory, anti-inflammatory, antimalarial, antiviral, antibacterial, antifungal, and hypolipidemic activities. Tulsi is referred to as "The matchless one" in Ayurveda and is used either alone or in combination with other herbs to cure chronic cough, cold, fever, bronchitis, and many other common illnesses. This review's objective is to give a succinct summary of the vast body of research on the pharmacology, phyto-chemistry, and many health advantages of tulsi. The World Health Organization (WHO) has pushed for the assessment of plants' medicinal potential for conditions for which we lack effective allopathic medications. This plant is a member of the Lamiaceae family, which is indigenous to the Old-World tropics and is used for both medical and religious purposes. The plant has been given many medical benefits not just in Ayurveda and Siddha but also in Greek, Roman, and Unani traditions. It is well-known as a medicinal plant and herbal tea in South Asia. Eugenol, cardinene, cubenol, borneol, linoleic acid, linolenic acid, oleic acid, palmitric acid, steric acid, Vallinin, Vicenin, Vitexin, Vallinin acid, Orientin, Circineol, Gallic Acid, vitamin A, vitamin C, phosphorus, and iron are among the chemical components isolated from various parts of the plant. Ocimum sanctum has been demonstrated to have a wide range of therapeutic qualities, including analgesic, anti-ulcer, immune-modulatory, anti-asthmatic, anticancer, anticonvulsant, antidiabetic, antihyperlipidemic, antistress, as well as beneficial memory enhancer and neuroprotectivepotential.