Prenatal Baicalein Exposure Induced Oxidative Stress And It's Recovery By Testosterone Administration During Postnatal Period In Male Wistar Mice

Excessive baicalein (BC; a flavonoid) intake during pregnancy period has been demonstrated to provoke oxidative stress an associated factor of male infertility in offspring. The role of testosterone depot in the recovery of damaged antioxidative system in prenatal BC exposed male mice was tested. For this female Wistar mice were administrated IP with 30, 60 and 90 mg/kg BW of BC on gestation days 11, 13, 15 and 17. F1 BC exposed males were sacrificed on post natal day (PND) 60 to assess the oxidative stress. The results showed a significant increase (P<0.0001) in testicular, liver and kidney malondialdehyde (MDA) levels in prenatal BC exposed males. In contrast to increased lipid peroxidation observed decrease in (P<0.001) levels of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) in prenatal BC exposed adult males in a dose dependent manner than controls. Administration of testosterone (4.16 mg/kg body weight) to BC exposed adult mice were normalized the levels of MDA, SOD and catalase in testis, liver and kidney and are comparable to controls. The administration of testosterone refused the antioxidant defence system and is proved in the present study.