Role of platelet rich fibrin (prf) in the regeneration of osseous defects in the jaws

Background: The healing potential of platelet growth factors has generated interest in using Platelet-Rich Fibrin (PRF) in osseous defects. A prospective study was performed to determine if periapical osseous defects treated with platelet-rich fibrin exhibit enhanced healing when along alloplastic bone graft material. Methods: Periapical defects in ten patients were treated with PRF and hydroxyapatite. Radiological evaluation of healing was done at 1month, 3 months and 6 months. Histologic evaluation was done at the end of 6 months. Results: Bone Healing was seen in the PRF treated sites. By the end of 3 months all the defects showed resorption of the graft material and by the end of 6 months all the defects showed osseous fill and matured bone formation. Conclusion: PRF along with bone graft material can be used for rapid regeneration of osseous defects.