Urinary tract infections caused by escherichia coli –antibiogram of nitrofurantoin versus ciprofloxacin at a tertiary care teaching hospital, Tirupati

Objective: Urinary tract infection is one of the most common bacterial infection. Escherichia coli is one of the commnest organism causing Urinary tract infection .Ciprofloxacin (fluoroquinolones) are the most commonly used as first line agents for treatment of urinary tract infections caused by Escherichia coli. Inappropriately excessive use of Ciprofloxacin (fluoroquinolones) has detrimental impact . Present study is antibiogram between Nitrofurantoin Versus Ciprofloxacin as first line agents for treatment of Urinary tract infection caused by Escherichia coli. Method: A total of 1205 urine samples collected between MAY2019 to October 2019 for culture and pathogens identified by conventional methods. Antibiotic susceptibility pattern determined by Kirby-Bauer disc diffusion method. Result: Among 1205 urine samples 203 samples shown culture positive, in this 39 samples shown Escherichia coli. Among them 28(71.7%) shown resistance to Ciprofloxacin and about 6 (15.3%) shown resistance to Nitrofurantoin. Conclusion: This study concludes that Nitrofurantoin is a good Ciprofloxacin sparing drug. .It is suggested that Nitrofurantoin might be the first choice for treatment of urinary tract infection caused by Escherichia coli ,needs further studies regarding its side effects