In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of tomato powder incorporated rice-based cold extrudates

Diabetes mellitus is a metabolic disorder and it is one of the free radical mediated diseases characterized by hyperglycemia. Among the various anti-diabetic therapeutic approaches one major strategy is reducing gastrointestinal absorption of glucose by inhibition of carbohydrate metabolizing enzymes α -amylase and α - glucosidase. The aim of this work was to evaluate the inhibitory activities of methanolic extracts of tomato powder incorporated rice based cold extrudates on α- amylase and α-glucosidase enzymes. The α- amylase inhibition assay showed that the methanolic extracts of control extrudates and TP extrudates were found to be 42.13 mg/ml and 40.47 mg /ml respectively exhibited 50% α- amylase inhibition activity at the mentioned concentrations. The α- glucosidase IC50 for the extrudate extracts of control extrudates and TP extrudates was found to be 52.50 mg/ml and 45.14 mg/ml respectively. The results of the work therefore clearly indicate the potential of these extracts to manage hyperglycemia.