Comparative study of insulin resistance in rural and urban in type 2 diabetes patients of muzaffarnagar district

Introduction: Insulin resistance is a feature of a number of clinical disorders, including T2D/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so-called metabolic syndrome. Insulin resistance in skeletal muscle manifests itself primarily as a reduction in insulin-stimulated glycogen synthesis due to reduced glucose transport. Material and Method: A cross-sectional study was conducted in Muzaffarnagar Medical College, Muzaffarnagar, U.P., India.. A total of 120 subjects of type 2 diabetes having an age group of 40-70 years were participated from urban and rural area of Muzaffarnagar District for determination of HOMA-estimated insulin resistance (HOMA-IR). Results: We found urban subjects had significantly higher fasting Glucose, fasting insulin and HOMA-IR values than rural subjects (p < 0.001). Conclusion: Environmental and lifestyle changes resulting from industrialization and migration to urban environment from rural settings may be responsible to a large extent, for this epidemic of insulin resistance in Indians.