Clinico-pathological features of differentiatedthyroid cancer and their impactson prognosis

Background: Differentiated thyroid cancer (DTC) is the most common type of thyroid cancer, with increasing incidence in last years, especially in female with three to four times in female comparing to male, also the relative increasing incidence of DTC in the mulitnodular goiter which was clearly observed in this study. Aim of the Work: This is a retrospective study which aims to analyze the clinical and pathological features of DTC and their impacts on the prognosis for patients with differentiated thyroid cancer who attended the Department of Clinical Oncology and Nuclear medicine in Ain Shams University Hospital between the years (2011-2016).Subjects and Methods: Data were collected and analyzed retrospectively from the files of the patients with DTC between the years (2011-2016), who attended the Clinical Oncology and Nuclear Medicine Department of Ain Shams University Hospital, Cairo – Egypt. Out of 102 patients with DTC, 21 patients were excluded due to insufficient data and loss of follow up, results obtained from 81 patients who were followed up until the end point of study. The mean period of follow up was 39.85±18.28 months. Results and Conclusion: The tumor size, lymph node metastases, capsular invasion, stage and grade were most important histopathological prognostic factors in relation to relapse risk, while the role of tumor multifocality and LVI were Insignificant. The role of different ablative doses of RAI131 was not significant in relation to risk of relapse in DTC patients. Recommendations: The use of proper risk stratification system by reassessing of relapse risk using the level of serum Tg and results of follow-up diagnostic images as markers of the response to initial surgery and radioactive iodine (RAI) remnant ablation. Further studies with larger number populations are needed to confirm the results obtained by the current work and to evaluate the role of gene mutations and other molecular markers which may affect the prognosis of DTC.