Coagulation parameters pre and post vaccination with astrazeneca among sudanese population at khartoum stat, 2022

Background: One of four vaccinations, the AstraZeneca vaccine, was given conditional approval to prevent COVID-19. It has been licensed and approved for use in more than 170 nations, and as of late November 2021, about 1 billion doses had been given worldwide. In order to produce the SARS-CoV-2 spike protein, which triggers an immune response, the vaccine uses a unique method that relies on a chimpanzee adenovirus vector (ChAdOx).This study aimed to estimate the changes in coagulation parameters among Sudanese vaccinated with the AstraZeneca vaccine. Materials and methods: This was a case-control study health facility base that was conducted in the vaccine center at the institute of public health which provides vaccine services. Participants who received the first dose of the AstraZeneca vaccine were included in the study's population, along with participants who appeared to be in good health. Two groups of samples were taken before and after the immunization (the case group). Of them, 83.3% were men and 16.7% were women. Of those, 43.3% were under 30 and 56.7% were over 30.The lab work was carried out at the research lab of the Gharb El-Niel College in Khartoum. Results: Platelets, fibrinogen, and D.dimer showed extremely significant differences (p value 0.000) between pre- and post-vaccination in the case group.There were no appreciable differences between the pre-vaccine case group and the control group when comparing the means of the platelets count, PT, APTT, INR, fibrinogen level, and D-dimer (p value 0.05); however, when comparing the post-vaccine case group, there was a significant rise in D-dimer and a significant fall in fibrinogen level (p value 0.000). Additionally there were insignificant variations in different parameters between pre and post-vaccine groups according to gender. Conclusion: According to the results of this study, the first dose of the AstraZeneca vaccine significantly increased the platelets count, PT, APTT, and D-dimer levels and significantly decreased the fibrinogen levels in the Sudanese persons.